When Patrick Quickly-Shiong, the billionaire businessman, medical researcher and proprietor of the Los Angeles Instances, opened a $250mn vaccine facility in Cape City in 2022, he was requested by Geordin Hill-Lewis, the town’s mayor, why he had chosen the Western Cape capital to make his funding.
In any case, Quickly-Shiong, a South African-born US citizen and entrepreneur, was introduced up in Port Elizabeth, studied on the College of Witwatersrand in Johannesburg and constructed his enterprise empire in California, Hill-Lewis explains.
“His instantaneous response was, ‘It’s the colleges. I would like a gentle provide of younger scientists and engineers and I can get them in Cape City,’” Hill-Lewis provides, recounting his assembly with Quickly-Shiong on the vaccine facility’s inauguration occasion attended by South Africa’s President Cyril Ramaphosa. “I believed that was an excellent comment.”
In addition to the College of Cape City, steadily ranked as the perfect on the continent, the town has different revered establishments of upper studying, together with the Cape Peninsula College of Know-how, the College of the Western Cape and, simply up the highway within the wine area, Stellenbosch College.
Just like the Cambridge-Oxford cluster within the UK, or Boston within the US, Cape City’s focus of universities permits a gentle stream of PhD and different analysis to be spun out into firms, making the town certainly one of Africa’s foremost start-up hubs, buyers say.
One instance is H3D, an built-in drug-discovery centre based by Kelly Chibale, a Zambian professor of natural chemistry on the College of Cape City.
In 2017, H3D grew to become the primary analysis centre on the continent to place an “African drug” — an antimalarial — into section II scientific trials. Final 12 months, earlier than the medical analysis funding setting was hit by cuts to the US Company for Worldwide Growth and the Nationwide Institutes of Well being, it was using 75 researchers, most of them with doctorates.
Cape City has additionally benefited from a broader development in South Africa, often called “semigration” by which rich individuals from Gauteng province, the commercial heartland, in addition to poorer ones from Jap Cape, flock to a metropolis that’s identified for having higher infrastructure and providers than Johannesburg, the nation’s financial capital.
Whereas that brings issues, resembling pushing up rents and home costs, it additionally provides to Cape City’s cluster impact. Amongst these shifting are banks and different monetary establishments, which have both moved their headquarters to Cape City or have seen rising numbers of employees relocate to the town.
“There’s been such a migration of the monetary providers business in South Africa to Cape City that there’s a rising ecosystem of enterprise capital finance accessible right here, which I feel helps the tech and start-up ecosystem,” Hill-Lewis says.
Mia von Koschitzky-Kimani, associate at Future Africa, which invests in early start-ups, just lately moved from Nairobi to Cape City looking for funding alternatives. Although it’s early days, she says, her first impression of the town’s start-up scene is that it is vitally totally different from those in Kenya and Nigeria.
In South Africa, she says, lots of the founders are white, with Black South Africans — for thus lengthy excluded from enterprise alternatives by racist apartheid legal guidelines — preferring to work within the public sector or for established firms. Her hunch is that Black-owned start-ups battle to entry worldwide capital, which doesn’t essentially goal South Africa, a notionally richer nation than most in Africa, that means that some companies could also be undervalued.
One other distinction is that, whereas Nigerian start-ups are most frequently created to resolve issues of logistics, finance and every day residing in Nigeria, lots of the companies in Cape City are addressing a global market, Koschitzky-Kimani says. A number of the pitch decks she receives are technically very refined, she provides, indicating a sure stage of talent and an ambition to resolve world issues.
“The quintessential South African entrepreneurs are constructing for South Africa or fascinated by the world outdoors Africa,” she says. “They suppose that Mexico may be nearer to South Africa than Lagos — and in some methods they may be proper.”

Cape City, with its relaxed life-style and proximity to mountains and sea, in addition to world-class vineyards, has additionally benefited from the development in digital nomads. South Africa’s authorities just lately lowered the minimal earnings thresholds for the visa that permits candidates to base themselves within the nation for as much as three years, although many distant staff merely pitch up and enter the nation as vacationers.
“Lots of people are right here for good, or for six months a 12 months when the climate is nice, however they’ve groups elsewhere on this planet,” says Koschitzky-Kimani. “We don’t see that in Lagos, and solely slightly in Nairobi.”
Opus, a group of founders “from concepts to sequence A”, has additionally simply arrange in Cape City, in addition to in Johannesburg. Jono Extra, Opus’s South African lead, says the boundaries to entry for start-ups have dropped massively, significantly due to advances in synthetic intelligence, which suggests there are typically too many early-stage companies chasing too few alternatives.
“There’s undoubtedly a giant entrepreneurial buzz in Cape City,” he says. “However it’s extremely laborious to get funding. You possibly can’t simply knock on the door and get a gathering.”
Extra has met dozens of firms in each Cape City and Johannesburg, starting from fintechs to at least one turning black soldier flies into pet meals. “It’s a really various group,” he says, pushing again on the concept founders are principally white. “There are from all walks of life, all colors, ethnicities, religions, and genders,” he says. “They name us the Rainbow Nation. I’m witnessing that at the beginning hand.”